| Item Type | Name |
|
Concept
|
Angioplasty, Balloon
|
|
Concept
|
Alkaline Phosphatase
|
|
Concept
|
Antigens, Differentiation
|
|
Concept
|
Antiviral Agents
|
|
Concept
|
Antibodies, Monoclonal
|
|
Concept
|
Histocompatibility Antigens Class II
|
|
Concept
|
Base Sequence
|
|
Concept
|
Autoradiography
|
|
Concept
|
Encephalomyelitis, Autoimmune, Experimental
|
|
Concept
|
Endoribonucleases
|
|
Concept
|
Cattle
|
|
Concept
|
Flavonoids
|
|
Concept
|
Codon
|
|
Concept
|
Genetic Vectors
|
|
Concept
|
Golgi Apparatus
|
|
Concept
|
Histamine
|
|
Concept
|
Cysteine
|
|
Concept
|
Dactinomycin
|
|
Concept
|
Cornea
|
|
Concept
|
Cycloheximide
|
|
Concept
|
Cysteine Endopeptidases
|
|
Concept
|
Dexamethasone
|
|
Concept
|
Dichlororibofuranosylbenzimidazole
|
|
Concept
|
Interleukins
|
|
Concept
|
Endothelium, Vascular
|
|
Concept
|
DNA Mutational Analysis
|
|
Concept
|
DNA, Neoplasm
|
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Ganglia
|
|
Concept
|
Heparitin Sulfate
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Exons
|
|
Concept
|
Ethylmaleimide
|
|
Concept
|
Cytomegalovirus
|
|
Concept
|
DNA Topoisomerases, Type II
|
|
Concept
|
DNA-Directed DNA Polymerase
|
|
Concept
|
Fibroblasts
|
|
Concept
|
Interferons
|
|
Concept
|
Introns
|
|
Concept
|
Enzyme Activation
|
|
Concept
|
Gene Expression Regulation
|
|
Concept
|
Genes, Viral
|
|
Concept
|
Glioma
|
|
Concept
|
Glioblastoma
|
|
Concept
|
Genetic Complementation Test
|
|
Concept
|
Genetic Engineering
|
|
Concept
|
DNA, Viral
|
|
Concept
|
Laryngeal Neoplasms
|
|
Concept
|
Enzyme Induction
|
|
Concept
|
Herpesvirus 4, Human
|
|
Concept
|
Escherichia coli
|
|
Concept
|
Hydroxamic Acids
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Hemagglutinins, Viral
|
|
Concept
|
Mice, Inbred CBA
|
|
Concept
|
Pneumonia, Viral
|
|
Concept
|
Exodeoxyribonucleases
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Pancreatic Neoplasms
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Mice, Nude
|
|
Concept
|
Mutation
|
|
Concept
|
Cricetinae
|
|
Concept
|
Hot Temperature
|
|
Concept
|
Herpes Simplex
|
|
Concept
|
Nucleic Acid Conformation
|
|
Concept
|
Trigeminal Ganglion
|
|
Concept
|
Microscopy, Electron
|
|
Concept
|
Phosphoprotein Phosphatases
|
|
Concept
|
Peptide Mapping
|
|
Concept
|
Plasmids
|
|
Concept
|
Protein Processing, Post-Translational
|
|
Concept
|
Regional Blood Flow
|
|
Concept
|
Rabbits
|
|
Concept
|
Interferon-gamma
|
|
Concept
|
ROC Curve
|
|
Concept
|
Genes, ras
|
|
Concept
|
RNA Splicing
|
|
Concept
|
Interleukin-6
|
|
Concept
|
Ribonuclease, Pancreatic
|
|
Concept
|
RNA Processing, Post-Transcriptional
|
|
Concept
|
Sensitivity and Specificity
|
|
Concept
|
Swine
|
|
Concept
|
Heterochromatin
|
|
Concept
|
Humans
|
|
Concept
|
Tosylphenylalanyl Chloromethyl Ketone
|
|
Concept
|
Interferon Type I
|
|
Concept
|
Tumor Necrosis Factor-alpha
|
|
Concept
|
Clinical Trials, Phase I as Topic
|
|
Concept
|
Urokinase-Type Plasminogen Activator
|
|
Concept
|
Histocompatibility Antigens Class I
|
|
Concept
|
Liver Neoplasms, Experimental
|
|
Concept
|
Transduction, Genetic
|
|
Concept
|
Herpesvirus 1, Human
|
|
Concept
|
Drug Resistance, Neoplasm
|
|
Concept
|
Genes, Essential
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Caspases
|
|
Concept
|
Chromosomes, Artificial, Bacterial
|
|
Concept
|
Cell Adhesion Molecules
|
|
Concept
|
Up-Regulation
|
|
Concept
|
Genome, Viral
|
|
Concept
|
Interleukin-4
|
|
Concept
|
Cysteine Proteinase Inhibitors
|
|
Concept
|
Interleukin-8
|
|
Concept
|
Interleukin-10
|
|
Concept
|
Mutagenesis, Site-Directed
|
|
Concept
|
Sequence Alignment
|
|
Concept
|
Microscopy, Immunoelectron
|
|
Concept
|
RNA Interference
|
|
Concept
|
Sequence Analysis, DNA
|
|
Concept
|
Genes, Immediate-Early
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
Ubiquitin Thiolesterase
|
|
Concept
|
Interferon-alpha
|
|
Concept
|
Gene Transfer Techniques
|
|
Concept
|
Gene Deletion
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Interleukin-12
|
|
Concept
|
Interferon-Stimulated Gene Factor 3
|
|
Concept
|
Interferon-Stimulated Gene Factor 3, gamma Subunit
|
|
Concept
|
Apoptosis Regulatory Proteins
|
|
Concept
|
Helix-Loop-Helix Motifs
|
|
Concept
|
Caspase 3
|
|
Concept
|
Gene Regulatory Networks
|
|
Concept
|
cdc25 Phosphatases
|
|
Concept
|
Encephalitis, Herpes Simplex
|
|
Concept
|
MAP Kinase Kinase Kinases
|
|
Concept
|
eIF-2 Kinase
|
|
Concept
|
Mutation, Missense
|
|
Concept
|
Janus Kinase 1
|
|
Concept
|
Fluorescent Antibody Technique, Indirect
|
|
Concept
|
Gene Knockout Techniques
|
|
Concept
|
AT Rich Sequence
|
|
Concept
|
Chromatin Assembly and Disassembly
|
|
Concept
|
Cyclin-Dependent Kinase 4
|
|
Concept
|
Chromatin Immunoprecipitation
|
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
|
Concept
|
COS Cells
|
|
Concept
|
Microscopy, Confocal
|
|
Concept
|
Cyclin B
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
5' Untranslated Regions
|
|
Concept
|
Oligonucleotide Array Sequence Analysis
|
|
Concept
|
3' Untranslated Regions
|
|
Concept
|
Mitogen-Activated Protein Kinase Kinases
|
|
Concept
|
Active Transport, Cell Nucleus
|
|
Concept
|
trans-Golgi Network
|
|
Concept
|
I-kappa B Proteins
|
|
Concept
|
Gene Expression Profiling
|
|
Concept
|
STAT3 Transcription Factor
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Mice
|
|
Concept
|
Ribonucleases
|
|
Concept
|
Host-Pathogen Interactions
|
|
Concept
|
Proto-Oncogene Proteins c-cbl
|
|
Concept
|
Retinoblastoma-Binding Protein 1
|
|
Concept
|
Cyclin D3
|
|
Concept
|
Real-Time Polymerase Chain Reaction
|
|
Concept
|
Umbilical Arteries
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Chemokine CXCL10
|
|
Concept
|
Immunoblotting
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Down-Regulation
|
|
Concept
|
STAT2 Transcription Factor
|
|
Concept
|
Serine Proteinase Inhibitors
|
|
Concept
|
CDC2 Protein Kinase
|
|
Concept
|
Cyclins
|
|
Concept
|
Open Reading Frames
|
|
Concept
|
Chemotherapy, Adjuvant
|
|
Concept
|
Transfection
|
|
Concept
|
Blotting, Northern
|
|
Concept
|
Reproducibility of Results
|
|
Concept
|
Genetic Therapy
|
|
Concept
|
Gene Expression Regulation, Viral
|
|
Concept
|
Simplexvirus
|
|
Concept
|
Herpesvirus 2, Human
|
|
Concept
|
G2 Phase
|
|
Concept
|
Genes, fos
|
|
Concept
|
Interferon-beta
|
|
Concept
|
Cyclin-Dependent Kinases
|
|
Concept
|
Interleukin-13 Receptor alpha1 Subunit
|
|
Concept
|
Gene Silencing
|
|
Concept
|
Xenograft Model Antitumor Assays
|
|
Concept
|
Statistics, Nonparametric
|
|
Concept
|
Interleukin-13
|
|
Concept
|
Histone Deacetylase Inhibitors
|
|
Concept
|
Phosphatidylinositol 3-Kinases
|
|
Concept
|
Cyclin A
|
|
Concept
|
Two-Hybrid System Techniques
|
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
|
Concept
|
E2F1 Transcription Factor
|
|
Concept
|
STAT1 Transcription Factor
|
|
Concept
|
Apoptosis Inducing Factor
|
|
Concept
|
I-kappa B Kinase
|
|
Concept
|
Cyclic AMP-Dependent Protein Kinase Type II
|
|
Concept
|
Immune Evasion
|
|
Concept
|
CDC2-CDC28 Kinases
|
|
Concept
|
Cellular Microenvironment
|
|
Concept
|
bcl-Associated Death Protein
|
|
Concept
|
Cyclin-Dependent Kinase 6
|
|
Concept
|
Host Cell Factor C1
|
|
Concept
|
Protein Phosphatase 2
|
|
Concept
|
Receptors, Urokinase Plasminogen Activator
|
|
Concept
|
Cyclin D2
|
|
Concept
|
Cyclin T
|
|
Concept
|
Antibodies
|
|
Concept
|
Cations
|
|
Concept
|
Cell Survival
|
|
Concept
|
Clinical Trials as Topic
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Data Interpretation, Statistical
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
DNA, Single-Stranded
|
|
Concept
|
Drug Administration Schedule
|
|
Concept
|
Epidermal Growth Factor
|
|
Concept
|
Ganglia, Spinal
|
|
Concept
|
Health Personnel
|
|
Concept
|
Kinetics
|
|
Concept
|
Microscopy, Fluorescence
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
|
Restriction Mapping
|
|
Concept
|
Transcriptional Activation
|
|
Concept
|
Gene Expression Regulation, Neoplastic
|
|
Concept
|
Cytokines
|
|
Concept
|
Mutagenesis, Insertional
|
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
|
Concept
|
Coculture Techniques
|
|
Concept
|
Cyclin D1
|
|
Concept
|
MicroRNAs
|
|
Concept
|
Cyclin-Dependent Kinase 9
|
|
Concept
|
Protein Kinase Inhibitors
|
|
Concept
|
p38 Mitogen-Activated Protein Kinases
|
|
Concept
|
Cyclin-Dependent Kinase 2
|
|
Academic Article
|
The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane.
|
|
Academic Article
|
Genetically engineered HSV in the treatment of glioma: a review.
|
|
Academic Article
|
Redefining virology.
|
|
Academic Article
|
Herpes simplex virus infections.
|
|
Academic Article
|
Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
|
|
Academic Article
|
cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor.
|
|
Academic Article
|
Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.
|
|
Academic Article
|
The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1.
|
|
Academic Article
|
Cell surface major histocompatibility complex class II proteins are regulated by the products of the gamma(1)34.5 and U(L)41 genes of herpes simplex virus 1.
|
|
Academic Article
|
Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.
|
|
Academic Article
|
The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific.
|
|
Academic Article
|
Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.
|
|
Academic Article
|
The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.
|
|
Academic Article
|
The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.
|
|
Academic Article
|
The first 30 minutes in the life of a virus: unREST in the nucleus.
|
|
Academic Article
|
Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus.
|
|
Academic Article
|
Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1.
|
|
Academic Article
|
Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
|
|
Academic Article
|
The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.
|
|
Academic Article
|
State and role of SRC family kinases in replication of herpes simplex virus 1.
|
|
Academic Article
|
Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus.
|
|
Academic Article
|
U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.
|
|
Academic Article
|
Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
|
|
Academic Article
|
Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.
|
|
Academic Article
|
Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
|
|
Academic Article
|
Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth.
|
|
Academic Article
|
US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis.
|
|
Academic Article
|
Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures.
|
|
Academic Article
|
Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
|
|
Academic Article
|
Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.
|
|
Academic Article
|
Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.
|
|
Academic Article
|
Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow.
|
|
Academic Article
|
ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
|
|
Academic Article
|
Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus.
|
|
Academic Article
|
The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.
|
|
Academic Article
|
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
|
|
Academic Article
|
An inquiry into the molecular basis of HSV latency and reactivation.
|
|
Academic Article
|
Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage.
|
|
Academic Article
|
Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia.
|
|
Academic Article
|
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
|
|
Academic Article
|
GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes.
|
|
Academic Article
|
Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA.
|
|
Academic Article
|
Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19.
|
|
Academic Article
|
hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells.
|
|
Concept
|
NF-KappaB Inhibitor alpha
|
|
Concept
|
Nectins
|
|
Concept
|
Ubiquitin-Specific Peptidase 7
|
|
Concept
|
Caspase Inhibitors
|
|
Concept
|
AU Rich Elements
|
|
Concept
|
Exosome Multienzyme Ribonuclease Complex
|
|
Grant
|
Selective Degradation of mRNA by Herpes Simplex Virus 1
|